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In high-dose methotrexate administration a temporary withdrawal of esomeprazole may need to be considered.
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8 of 133 patients with normal lfts on methotrexate had an alt serum concentration at least 3 times the uln with leflunomide addition.
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Conversely, methotrexate can increase the occurrence of the anemia caused by sulfonamides because methotrexate also causes folic acid deficiency.
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In addition to high-dose methotrexate with leucovorin rescue, these agents may include doxorubicin, cisplatin, and the combination of bleomycin, cyclophosphamide and dactinomycin bcd in the doses and schedule shown in the table below.
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Methotrexate 20 mg m2 orally increased 6-mercaptopurine auc by approximately 31 and methotrexate 2 or 5 g m2 intravenously increased 6-mercaptopurine auc by 69 and 93 , respectively.
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methotrexate is a substrate of the breast cancer resistance protein bcrp ; oral tedizolid inhibits bcrp in the intestine.