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When 6-mercaptopurine or azathioprine is given concurrently with allopurinol, only one-quarter of the usual dose of 6-mercaptopurine or azathioprine should be given because inhibition of xanthine oxidase will prolong their activity.

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they may affect anyone who is sensitive to allopurinol, and this sensitivity cannot always be predicted.

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allopurinol and its primary active metabolite, oxipurinol, are eliminated by the kidneys; therefore, changes in renal function have a profound effect on dosage.

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allopurinol may interfere with hepatic metabolism of phenytoin, but the clinical significance of this interaction is unknown.

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your doctor then will most likely prescribe you either allopurinol, colchicine, phobenecid or nsaids to get rid of uric acid before it crystallizes and causes you a .

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a skin rash may also indicate an allergy to allopurinol.

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